Understanding the disease
How and why CADASIL affects the brain's small blood vessels — and why it can look so different from one person to another, even within the same family.
Where the science is
CADASIL research
CADASIL research is moving. Over the past thirty years, the field has gone from knowing very little to identifying the gene that causes CADASIL, understanding what it does to the small blood vessels of the brain, and starting to explore possible treatments. The next decade could bring meaningful progress.
Fund CADASIL research directly.
Our research fundraising is administered by the Sunnybrook Foundation. Donations through our page support CADASIL research at Sunnybrook.
Four broad areas of active work.
Better ways to measure change
CADASIL usually changes slowly, so it can be hard to tell quickly whether a treatment is working. Researchers are working on better ways to see how the disease is changing over time.
Possible treatments
Early-stage work is under way on new approaches that could one day slow or change how CADASIL progresses. None of these are yet proven or available as treatments.
Building the research base
Well-organized information collected from patients over time is what makes future studies possible — including registries, natural-history data, and biological samples.
Why patients matter
Research moves when the community shows up.
For a rare condition like CADASIL, every patient and family who takes part in a study, joins a registry, or shares information helps the next study happen sooner. That participation is a big part of what makes progress possible.
Contact us about research opportunities →External link to ClinicalTrials.gov